Epigallocatechin gallate (EGCG) is a catechin compound of the flavonoid family and is extracted from the green tea plant Camellia sinensis. It has been used as an anti-cancer, anti-viral and anti-bacterial compound. The cababilities of EGCG have been shown to be caused through antioxidant activity, enzyme inhibition and stimulation of specific metabolic pathways.
EGCG anti-cancer activities are exerted through controlling cell signaling pathways. It has been shown that EGCG directly inhibits cyclin dependent kinases and induces apoptotic proteins p21 and p27. EGCG has also been used to trigger apoptosis by Bax oligomerization which subsequently caspase activation.
Anti-viral activities observed in EGCG occur by inhibiting RNA polymerase and neuraminidase, a key influenza enzyme. EGCG has also been shown to prevent the fusion of viral membranes to host cells and to terminate reactive oxidative species (ROS) produced by oxidative stress. Its anti-viral capabilities were heavily dependent on a galloyl group present on the catechin skeleton.
EGCG has been shown to have a broad spectrum of antibacterial activity against gram positive and some gram negative bacteria. It is used synergistically with penicillin binding protein inhibitors because both target peptidoglycan on the cell wall. While the exact mechanism is not known, research on EGCG activity indicates bacterial cell wall damage by direct peptidoglycan binding.
Product SpecificationsEpigallocatechingallateEpigallocatechin-3-gallate(–)-Epigallocatechin-3-O-gallate
Formula: C22H18O11
MW: 458.37 g/mol
Storage/Handling: Store desiccated at 4°C.
PubChem Chemical ID: 65064
IPTG, X-Gal and X-Gluc
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没错!最开始,Gold Biotechnology只生产这三个产品,30年后的今天,Goldbio的产品已经超过3000种,涵盖:
琼脂糖树脂
抗生素
生化试剂
缓冲液
克隆与诱导
培养基添加剂
洗涤剂
DNA蛋白质电泳
酶、抑制剂和底物
生长因子
植物研究
蛋白质表达与纯化
还原剂……
目前Goldbio最核心的产品是:荧光素钾盐,X-gluc, 双丙氨磷,草胺磷 和 X-α-gal