Chicoric acid is a hydroxycinnamic acid that occurs in a variety of plants such as Cichorium intybus and Echinacea purpurea. It has been used as an anti-viral, anti-inflammatory, antioxidant and an insulin enhancer.

Chicoric acid has specifically been used as an inhibitor of integrase enzymes in human immunodeficiency virus type one (HIV1). Inhibition of this enzyme prevents viral genetic material from being incorporated into host DNA. It specifically shows activity towards HIV1 and not HIV2.

Chicoric acid presence for in vivo and in vitro studies have shown a stimulation in AMP-activated protein kinase (AMPK) expression. The upregulation in AMPK expression results in the observed antioxidant, anti-inflammatory and insulin enhancing effects. Anti-oxidizing protein synthesis has been increased through AMPK stimulation. AMPK has also been shown to diminish inflammatory responses by increasing interleukin 10 synthesis (IL10), an anti-inflammatory cytokine. Chicoric acid stimulation of AMPK inhibits glucose-6-phosphate formation, promoting glucose utilization. The release of insulin by pancreatic β-islet cells has been correlated with direct stimulation by chicoric acid.

Product SpecificationsChicoric acidCichoric acidDicaffeoyltartaricacid

Formula: C₂₂H₁₈O₁₂

MW: 474.37 g/mol

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 5281764

IPTG, X-Gal and X-Gluc

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没错！最开始，Gold Biotechnology只生产这三个产品，30年后的今天，Goldbio的产品已经超过3000种，涵盖：

琼脂糖树脂

抗生素

生化试剂

缓冲液

克隆与诱导

培养基添加剂

洗涤剂

DNA蛋白质电泳

酶、抑制剂和底物

生长因子

植物研究

蛋白质表达与纯化

还原剂……

目前Goldbio最核心的产品是：荧光素钾盐，X-gluc， 双丙氨磷，草胺磷 和 X-α-gal