Bacitracin is a cyclic polypeptide antibiotic isolated from Bacillus subtilis.It is made up of a variety of antimicrobial peptide fractions including A, A1, B, B1, B2, C, D, E, F, G, and X.This standard grade product is a mixture of these fractions, with bacitracin A exhibiting the most potent antimicrobial activity.Bacitracins B1 and B2 exhibit about 90% of the antimicrobial activity of bacitracin A when together.Other forms of bacitracin have not been studied extensively, but may have negligible antimicrobial properties. Bacitracin is freely soluble in aqueous solution.

Bacitracin targets the cell wall of gram-positive organisms such as Streptococcus pyogenes and Staphylococcus aureus.Bacitracin also functions as a useful tool to distinguish between group A and group B β-hemolytic Streptococcus species, which are susceptible and resistant, respectively.

Bacitracin functions through inhibiting phosphorylation of bactoprenol, a step essential to synthesize peptidoglycan.Consequently, cell lysis occurs.Bacitracin resistance is conferred through a BcrABC transporter that pumps bacitracin out of cells or through BacA which allows phosphorylation of bactoprenol via an alternative biosynthesis pathway.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product SpecificationsBacitracin, USP Grade

Formula: C₆₆H₁₀₃N₁₇O₁₆S

MW: 1,422.69 g/mol

Storage/Handling: Store at 2-8 °C.

PubChem Chemical ID: 24891503

IPTG, X-Gal and X-Gluc

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没错！最开始，Gold Biotechnology只生产这三个产品，30年后的今天，Goldbio的产品已经超过3000种，涵盖：

琼脂糖树脂

抗生素

生化试剂

缓冲液

克隆与诱导

培养基添加剂

洗涤剂

DNA蛋白质电泳

酶、抑制剂和底物

生长因子

植物研究

蛋白质表达与纯化

还原剂……

目前Goldbio最核心的产品是：荧光素钾盐，X-gluc， 双丙氨磷，草胺磷 和 X-α-gal