Neomycin is a broad-spectrum aminoglycoside antibiotic isolated from Streptomyces species.It targets gram-negative and gram-positive bacteria.Neomycin can also be used as a selection agent for prokaryotic cells transformed with the neo gene or NPT II resistance gene and to study toxic antibacterial side effects.In addition, neomycin is a calcium channel protein inhibitor and DNase I inhibitor.It can be used in a variety of cell culture applications.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

In addition to its use in antimicrobial susceptibility testing, neomycin sulfate is used for food testing in TSN agar to select for Clostridium perfringens. It inhibits growth of Enterobacteria and Clostridium bifermentans.Neomycin can be used to negatively select for plants transformed with plasmid containing Agrobacterium mediated transformation resistance and to cells containing pcDNA3 resistance plasmids.

Product SpecificationsNeomycin Sulfate, USP Grade

Formula: C₂₃H₄₆N₆O₁₃ ∙ 3H₂SO₄

MW: 908.88 g/mol

Storage/Handling:Store at 4°C.

PubChem Chemical ID: 44134844

IPTG, X-Gal and X-Gluc

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没错！最开始，Gold Biotechnology只生产这三个产品，30年后的今天，Goldbio的产品已经超过3000种，涵盖：

琼脂糖树脂

抗生素

生化试剂

缓冲液

克隆与诱导

培养基添加剂

洗涤剂

DNA蛋白质电泳

酶、抑制剂和底物

生长因子

植物研究

蛋白质表达与纯化

还原剂……

目前Goldbio最核心的产品是：荧光素钾盐，X-gluc， 双丙氨磷，草胺磷 和 X-α-gal